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Indications and Dosage
Intramuscular
Adjunct to radioiodine for thyroid remnant ablation, Adjunctive diagnostic tool with serum thyroglobulin testing in post-thyroidectomy patients for remnant thyroid tissue Adult: 2 doses of 0.9 mg at 24-hr interval into the gluteal muscle of post-thyroidectomy patients.
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Reconstitution
Add 1.2 mL of sterile water for inj in a vial containing 1.1 mg to provide a soln containing 0.9 mg/mL.
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Special Precautions
Patient w/ significant residual thyroid tissue, cardiac disease, extensive metastases, serious underlying illness, risk of stroke (e.g. history of migraine headaches, smoker), women on oral contraceptives. Pregnancy and lactation.
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Adverse Reactions
Significant: Transient increase in serum thyroid hormone, stroke or symptoms predictive of stroke (e.g. unilateral weakness); enlargement of residual thyroid tissue or metastases causing pain and acute symptoms (depending on the location).
Nervous: Dizziness, fatigue, headache, asthenia, flu-like illness, paraesthesia, insomnia, tremors. CV: Palpitations. GI: Nausea, vomiting, diarrhoea. Resp: Nasopharyngitis. Musculoskeletal: Back pain. Dermatologic: Hyperhidrosis. Others: Discomfort at inj site. Potentially Fatal: Drug-induced hyperthyroidism. |
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IM/Parenteral: C
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Patient Counseling Information
This drug may cause dizziness and headache, if affected, do not drive or operate machinery.
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Monitoring Parameters
Monitor neurologic adverse events (e.g. hemiplegia, hemiparesis, stroke, weakness), dyspnoea, dysphonia, stridor, or other symptoms of local tumour growth.
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Overdosage
Symptoms: Nausea, weakness, dizziness, headache, vomiting, hot flashes. Management: Supportive treatment.
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Action
Description: Thyrotropin alfa, a recombinant human TSH, binds to TSH receptors on thyroid epithelial cells stimulating iodine uptake and organification, and synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3) and thyroxine (T4).
Pharmacokinetics: Absorption: Time to peak plasma concentration: 3-24 hr. Excretion: Elimination half-life: 25±10 hr. |
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Storage
Store between 2-8°C. Protect from light.
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MIMS Class
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ATC Classification
H01AB01 - thyrotropin alfa ; Belongs to the class of thyrotropin. Used in anterior pituitary lobe hormone and analogue preparations.
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References
Anon. Thyrotropin alfa. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com
. Accessed 04/05/2017. Buckingham R (ed). Thyrotrophin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/05/2017. Joint Formulary Committee. Thyrotropin alfa. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/05/2017. Thyrogen Injection, Powder, For Solution (Genzyme Therapeutics). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/05/2017.
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